Unit 2 Case Connections – Video Presentation Assignment | Get Paper Help

For the Unit 2 Case Connections assignment, you will address two of the four case connection problems in an original 10-minute video presentation. To earn full credit, you will need to describe why your chosen answer is correct while also discussing why the other answers are incorrect. Your presentation will be graded on your logic and accuracy as well as on the clarity and organization of the overall assignment. Create a script for your presentation. You will submit your script along with your video presentation. References in AMA format are also required. You may utilize any resources you like as you discuss your solution and methods, but you should include a reference page at the end of your script. This assignment is submitted through SafeAssign which is a plagiarism prevention tool that allows your instructor to check the originality of a homework submission. If your submission is has a SafeAssign score of >50% your instructor may request that you resubmit your assignment or justify this level of percent overlap. Scores of >50% raise concern over academic integrity. Record your presentation as a video using a free screencast application such as Screencast-o-matic. Required: You must begin your video by showing yourself full-screen, looking directly into the camera, and clearly stating your full name while holding up a piece of paper on which your full name and the date are clearly written in bold writing. If you fail to do so, the assignment will not be graded. You will have to submit it again prior to your course end date. Upload your video to YouTube. WHAT I NEED U TO DO IS NOT TO DO THE VIDEO BUT INSTEAD ANSWER IT IN WRITING AND I WILL RECORD THE VIDEO

Unit 2 Case Connections Video
Description:
Case connections are short scenarios or puzzles based on the information from the current unit of study.
For the Unit 2 Case Connections assignment, you will address two case connection problems in an
original 10-minute video presentation.
To earn full credit, you will need to describe why your chosen answer is correct while also discussing
why the other answers are incorrect. Your presentation will be graded on your logic and accuracy as well
as on the clarity and organization of the overall assignment.
● Create a script for your presentation. You will submit your script along with your video
presentation.
○ References in AMA format are also required. You may utilize any resources you like as
you discuss your solution and methods, but you should include a reference page at the
end of your script.
○ This assignment is submitted through SafeAssign which is a plagiarism prevention tool
that allows your instructor to check the originality of a homework submission. If your
submission is has a SafeAssign score of >50% your instructor may request that you
resubmit your assignment or justify this level of percent overlap. Scores of >50% raise
concern over academic integrity.
● Record your presentation as a video using a free screencast application such as
Screencast-o-matic .
○ Required: You must begin your video by showing yourself full-screen, looking directly
into the camera, and clearly stating your full name while holding up a piece of paper on
which your full name and the date are clearly written in bold writing. I f you fail to do so,
the assignment will not be graded. You will have to submit it again prior to your course
end date.
○ Upload your video to YouTube.
For help recording your case connections presentation using Screencast-o-matic and uploading your
video to YouTube, go to https://success.une.edu/blackboard-support/recording-a-presentation/
Case 1:
Pyruvate Kinase (PK) catalyzes the rate-limiting, ATP-generating step of glycolysis in which
phosphoenolpyruvate (PEP) is converted to pyruvate. Multiple isoenzymes of pyruvate kinase exist in
mammals: type L, which is found in the liver and kidneys; type R, which is expressed in erythrocytes;
type M1, which is found in tissues such as muscle and brain; and type M2, which is present in
self-renewing cells such as embryonic and adult stem cells.
1) Under normal conditions, describe all the ways in which pyruvate kinase is regulated in the cell?
UNE Online _ Case connections
Many types of cancer cells are predominantly glycolytic and over express the oncoprotein MYC.
Interestingly, the classical oncoprotein MYC has been found to promote preferential expression of
pyruvate kinase type M2 over pyruvate kinase type M1 .
The isoform M2 is characteristically found in a low activity state and is ineffective at promoting glycolysis
(When compared to pyruvate kinase type L or type M1).
2) This logic seems counter-intuitive for a glycolytic tissue. What is the rationale for this
mechanism and what other pathways may cancer cells be diverting substrate to?
Case 2:
Regulation of glucose uptake by the cell
The above brain MRI shows a large glioblastoma tumor with areas of necrosis within the tumor (tumor is
the bright white area within the brain field on MRI). On the right is a PET scan from the same individual
following administration of fluorescently labeled D-glucose.
Use the following series of questions to determine how / if glucose uptake differs in the tumor when
compared to the surrounding tissues.
In normal tissue, how is glucose uptake regulated in the following tissues:
● Liver
● Skeletal Muscle
● Brain
● Adipose
How does glucose uptake in normal tissue compare to glucose uptake by tumor cells in the above image
and why would this be advantageous to the invasive tumor?
What modifications may have occurred in cancer cells to alter glucose uptake as predicted above?
UNE Online _ Case connections
Case 3:
A 5-year-old boy is brought to the pediatrician’s office for an annual visit. The mother reports he has
been a sickly infant and often appears drowsy. She also has concerns over her son’s persistent thirst and
frequent urination. Blood samples are taken for insulin measurements at time zero and 1 hour after a
glucose loading test. The results of this testing are illustrated in the table below:
Baseline blood sample 1 hour after glucose load
Patient Control Patient Control
Serum insulin levels (mU/L) 0.8 6 +/- 2 5 40 +/- 11
What is this information likely to suggest about the underlying biochemical basis for the patient
symptoms?
What would you predict the patients’ fasted blood glucose levels to be given his current condition? (e.g.
above normal range; within the normal range; below the normal range)
List 2 regulatory enzymes that are likely to be active in this individuals’ current condition.
Case 4
A previously healthy 2-month-old female presents with jittery spells several hours after breastfeeding.
Her mother reports she has not given the baby anything to eat other than breastmilk since birth. The
baby has only recently been sleeping for more than 2 hours between feedings and that’s when the
mother reports these symptoms started. Laboratory results are consistent with hypoglycemia (low blood
glucose) but are otherwise unremarkable. Epinephrine is administered and there is no increase in
blood glucose but there is an increase in blood lactate (Hint: think of what pathways would be
activated by this hormone).
Physical exam reveals a liver edge 4 cm below the right costal margin. Percussion of the right chest and
abdomen confirms hepatomegaly (enlarged liver).
Blood glucose levels increase after breastfeeding but she cannot maintain blood glucose levels within a
normal range during fasting.
Based on the information above, which of the following is the most likely diagnosis of this patient?
a) Hereditary fructose intolerance
b) Galactosemia
c) Glycogen storage disease (inability to use glycogen)
d) Glucose 6-phosphate dehydrogenase deficiency