Themes and Sickle Cell Disease Assignment | Online Assignment

Using the PowerPoint files and videos 1a and 1c, choose one of the course themes and describe how that theme is illustrated by Sickle Cell DiseaseIntroduction
Themes
The Scientific Method
1
Hierarchy
of Life
2
THEMES
1. Emergent properties
2. Structure and function are related at all
levels
3. Cell theory
4. Hereditary information
5. Information is exchanged with the
cellular environment; cells can regulate
their internal environment
6. Evolution
3
1
2
3
Lecture 1 7-2-19 B140 SS19 5/8/2020
2
Emergent Properties
http://www.mrgscience.com/uploads/2/0/7/9
/20796234/emergent-med_orig.jpeg
Mr. G. Science
4
Structure-Function Relationships
Bugg et al., Yang Zhang Lab, University of Michigan
http://zhanglab.ccmb.med.umich.edu/image/lock_key.gif
Structure-based Drug Design for Inhibition of Purine Nucleoside
Phosphorylase (PNP)
(a) PNP active site interacts with individual nucleosides
(b) cleaves the purine from the sugar of nucleoside
(c) drug blocks the binding pocket and inhibits the activity of the PNP
enzyme
5
The Cell Theory
•The cell is the fundamental unit
of life. All living things are made
of cells.
•All cells come from other cells.
Spontaneous generation does
not occur.
4
5
6
Lecture 1 7-2-19 B140 SS19 5/8/2020
3
Francesco Redi Experimentation
Louis Pasteur Experimentation
All organisms are made of
either a single cell or an ensemble of cells.
7
8
9
Lecture 1 7-2-19 B140 SS19 5/8/2020
4
The Cell
Theory
Drawing of the
structure of cork
by Robert Hooke
that appeared in
Micrographia.
https://upload.wikimedia.
org/wikipedia/commons/
thumb/1/17/Cork_Microg
raphia_Hooke.png/220p
x-
Cork_Micrographia_Hoo
ke.png 10
Hereditary Information
http://www.sciencemag.org/sites/default/files/styles/article_main_large/public/images/DNA%20sequ
ence_0.jpg?itok=BIPH-9em 11
The Cell Regulates Internal
Environment and Interacts with
Exterior Environment
Cellular
Homeostasis
Receptors
and
Transporters
http://www.mrgscience.com/uploads/2/0/7/9/20796234/5387454.jpg?301 12
10
11
12
Lecture 1 7-2-19 B140 SS19 5/8/2020
5
Major transitions in evolution of the endomembrane system.
Joel B. Dacks, and Mark C. Field J Cell Sci 2007;120:2977-
2985
© The Company of Biologists Limited 2007
Molecular and Cellular Evolution
https://evolution.berkeley.edu/evolibrary/print/printable_template.php?news_id=200305_coronavirus&context=
THEMES
1. Emergent properties
2. Structure and function are related at all
levels
3. Cell theory
4. Hereditary information
5. Information is exchanged with the
cellular environment; cells can regulate
their internal environment
6. Evolution
15
13
14
15