Nova Southeastern University Clinical Guideline for Nursing Practice Essay 1. Provide a brief overview of the selected evidenced-based guideline relating t

Nova Southeastern University Clinical Guideline for Nursing Practice Essay 1. Provide a brief overview of the selected evidenced-based guideline relating to nursing practice. (provided in the attachments)

2. Summarize one recommendation from the chosen evidenced-based guideline.

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a. Discuss how the recommendation could be utilized to improve patient outcomes.

b. Determine how the recommendation could be implemented into professional nursing practice.

4. The scholarly paper should be in narrative format, 3 to 5 pages excluding the title and reference page.

5. Include an introductory paragraph, purpose statement, and a conclusion.

6. Include level 1 and 2 headings to organize the paper.

7. APA format is required (attention to spelling/grammar, a title page, a reference page, and in-text citations).

8. Use the sources on the attachments for your references. Articles
Effectiveness of fluticasone furoate plus vilanterol on asthma
control in clinical practice: an open-label, parallel group,
randomised controlled trial
Ashley Woodcock*, Jørgen Vestbo*, Nawar Diar Bakerly, John New, J Martin Gibson, Sheila McCorkindale, Rupert Jones, Susan Collier,
James Lay-Flurrie, Lucy Frith, Loretta Jacques, Joanne L Fletcher, Catherine Harvey, Henrik Svedsater, David Leather, on behalf of the Salford Lung
Study Investigators†
Summary
Background Evidence for management of asthma comes from closely monitored efficacy trials done in highly selected
patient groups. There is a need for randomised trials that are closer to usual clinical practice.
Methods We did an open-label, randomised, controlled, two-arm effectiveness trial at 74 general practice clinics in
Salford and South Manchester, UK. Patients aged 18 years or older with a general practitioner’s diagnosis of symptomatic
asthma and on maintenance inhaler therapy were randomly assigned to initiate treatment with a once-daily inhaled
combination of either 100 μg or 200 μg fluticasone furoate with 25 μg vilanterol or optimised usual care and followed up
for 12 months. The primary endpoint was the percentage of patients who achieved an asthma control test (ACT) score
of 20 or greater or an increase in ACT score from baseline of 3 or greater at 24 weeks (termed responders), in patients
with a baseline ACT score less than 20 (the primary effectiveness analysis population). All effectiveness analyses were
done according to the intention-to-treat principle. This study is registered with ClinicalTrials.gov, number NCT01706198.
Findings Between Nov 12, 2012, and Dec 16, 2016, 4725 patients were enrolled and 4233 randomly assigned to initiate
treatment with fluticasone furoate and vilanterol (n=2114) or usual care (n=2119). 1207 patients (605 assigned to usual
care, 602 to fluticasone furoate and vilanterol) had a baseline ACT score greater than or equal to 20 and were thus
excluded from the primary effectiveness analysis population. At week 24, the odds of being a responder were higher for
patients who initiated treatment with fluticasone furoate and vilanterol than for those on usual care (977 [71%] of 1373
in the fluticasone furoate and vilanterol group vs 784 [56%] of 1399 in the usual care group; odds ratio [OR] 2·00 [95% CI
1·70–2·34], p20 or missing*)
1514 included in the primary effectiveness analysis population
133 in primary effectiveness analysis population withdrawn before
the 52-week visit or lost to follow-up
9 adverse events
3 protocol deviations
11 reached protocol-defined stopping criteria
76 lost to follow-up
16 at investigator discretion
18 withdrew consent
1512 included in the primary effectiveness analysis population
148 in primary effectiveness analysis population withdrawn before
the 52-week visit or lost to follow-up
12 adverse events
4 protocol deviations
7 reached protocol-defined stopping criteria
75 lost to follow-up
27 at investigator discretion
23 withdrew consent
1381 patients in the primary effectiveness analysis population
completed the 52-week visit
1364 patients in the primary effectiveness analysis population
completed the 52-week visit
1946 in the to…
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