Evolution of vaccine development against pneumococcal pneumonia.

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Topic: Evolution of vaccine development against pneumococcal pneumonia.
-The word limit is 4000-6000 words.
-Provide me or send to me all references that you will use in my paper because I need the abstract for each reference you will use.
-Table of content is needed.
These are the organization and outlines for the assignment:
– Abstract.
¢ Introduction to the topic:
¢ Background information about pneumococcal pneumonia infection:
¢ The causative agent
¢ Disease syndromes caused by it.
¢ Characteristics of the diseases.
¢ Manifestations of the disease.
¢ Diagnosis and the current therapeutic strategies of the disease.
¢ Epidemiology including the spread, worldwide incidence, prevalence, pandemic, significance to the public health and the economic cost.
¢ Source and reservoir+ incubation period.
¢ Modes of the transmission of the pathogen.
¢ Mechanisms of pathogenesis:
¢ Virulence factors and those that need attention in vaccine development.
¢ Risk factors.
¢ People at risk.
¢ Evolution of vaccine development against pneumococcal infection:
¢ Immunization and prophylaxis against pneumonia.
¢ Serotype diversity.
¢ The specificity of immune response against serotypes.
¢ Types of vaccines undergoing trials.
¢ Immunization schedule.
¢ Current vaccines undergoing trials.
¢ Their benefits and limitations.
¢ The novel alternatives for third generation pneumococcal vaccines.
¢ Burden and cost effectiveness of vaccination.
¢ Current status of the development of improved vaccines and the ways by which the improved vaccines will be better than the currently used vaccines.
¢ Discussion:- Indicate all of previous different evolutions.
¢ Conclusion + future directions for vaccine development.

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