Question: Ethanol (Mr 46) in the body is oxidized to acetaldehyde by liver alcohol dehydrogenase (LADH). Other alcohols are also oxidized by LADH. For example, methanol (Mr 32), which is mildly intoxicating, is oxidized by LADH to the quite toxic product of formaldehyde. The toxic effects of ingesting methanol (a component of many commercial solvents) can be reduced by administering ethanol. The ethanol acts as a competitive inhibitor of methanol by displacing it from LADH. This provides sufficient time for the methanol to be harmlessly excreted by the kidneys. If an individual has ingested 100 mL of methanol (a lethal dose), how much 100 proof whiskey (50% ethanol by volume) must be imbibed to reduce the activity of the LADH towards methanol to 5% of its original value? The adult human body contains ~40L of aqueous fluids throughout which ingested alcohols are rapidly and uniformly mixed. The densities of ethanol and methanol are both 0.79 g/cm3. Assume the Km values of LADH for ethanol and methanol to be 10-3 M and 10-2 M, respectively, and that Ki = KM for ethanol
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