Huntington’s disease is a rare autosomal dominant trait (lethal in the homozygous dominant condition). The mutation is an expansion of a nucleotide repeat in the DNA that encodes the huntingtin protein. Normal individuals have between 6-35 copies of a CAG repeat within the gene. Affected individuals can have between 36-121 repeats. In aIDition, as the number of repeated triplets (CAG) increases, the age of onset in the patient decreases. Individuals with this disease suffer from progressive neurodegeneration eventually resulting in death.
a. A 20-year old single woman whose father died of Huntington’s disease is concerned about her risk of eventually developing the disease. What is the probability that she will eventually get HD, if her mother is phenotypically normal?
b. The HD gene has been sequenced and its location on chromosome 4 has been well characterized. The entire DNA sequence of chromosome 4 has been sequenced. A genetic screen can definitively determine whether this woman has the HD mutant allele.
i. What reaction components would be needed to PCR amplify the HD alleles from her genome?
ii. Once the alleles were amplified, how could you compare the size of her alleles to alleles from other individuals?
iii. If this woman was heterozygous at the HD locus, describe the sizes of the two PCR-amplified alleles and how they would compare to amplified alleles from both of her parents.
Why Work with Us
Top Quality and Well-Researched Papers
We always make sure that writers follow all your instructions precisely. You can choose your academic level: high school, college/university or professional, and we will assign a writer who has a respective degree.
Professional and Experienced Academic Writers
We have a team of professional writers with experience in academic and business writing. Many are native speakers and able to perform any task for which you need help.
Free Unlimited Revisions
If you think we missed something, send your order for a free revision. You have 10 days to submit the order for review after you have received the final document. You can do this yourself after logging into your personal account or by contacting our support.
Prompt Delivery and 100% Money-Back-Guarantee
All papers are always delivered on time. In case we need more time to master your paper, we may contact you regarding the deadline extension. In case you cannot provide us with more time, a 100% refund is guaranteed.
Original & Confidential
We use several writing tools checks to ensure that all documents you receive are free from plagiarism. Our editors carefully review all quotations in the text. We also promise maximum confidentiality in all of our services.
24/7 Customer Support
Our support agents are available 24 hours a day 7 days a week and committed to providing you with the best customer experience. Get in touch whenever you need any assistance.
Try it now!
How it works?
Follow these simple steps to get your paper done
Place your order
Fill in the order form and provide all details of your assignment.
Proceed with the payment
Choose the payment system that suits you most.
Receive the final file
Once your paper is ready, we will email it to you.
No need to work on your paper at night. Sleep tight, we will cover your back. We offer all kinds of writing services.
No matter what kind of academic paper you need and how urgent you need it, you are welcome to choose your academic level and the type of your paper at an affordable price. We take care of all your paper needs and give a 24/7 customer care support system.
Admission Essays & Business Writing Help
An admission essay is an essay or other written statement by a candidate, often a potential student enrolling in a college, university, or graduate school. You can be rest assurred that through our service we will write the best admission essay for you.
Our academic writers and editors make the necessary changes to your paper so that it is polished. We also format your document by correctly quoting the sources and creating reference lists in the formats APA, Harvard, MLA, Chicago / Turabian.
If you think your paper could be improved, you can request a review. In this case, your paper will be checked by the writer or assigned to an editor. You can use this option as many times as you see fit. This is free because we want you to be completely satisfied with the service offered.